Naturally bounded on the north by the Yakima Valley appellation and on the south by the Columbia River.
Located in Southwest Washington – total area is 570,000 acres (230,679 hectares) of which about 6,040 acres are planted to grapes.

Primary grape varieties – Chardonnay, Sauvignon Blanc, Riesling, Cabernet Sauvignon, Merlot, and Syrah.

Proximity to the Columbia River and a distinctive topography benefit the area by moderating temperature extremes, providing steep, south-facing slopes for optimum vineyard locations, and providing quick-draining silty loam soils.

Elevations range from 1,800 feet at the area's northern boundary to 200 feet at its southern one.

The outstanding sites that have been developed in this area are Canoe Ridge, Alder Ridge, and Zephyr Ridge.

Growers have raised grapes in the Horse Heaven Hills region since 1972.

There are at least 20 vineyards and 4 commercial wineries within the region.